Gambaran Sumsum Tulang pada Myelodysplastic Syndrome (MDS)

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Gambaran sumsum tulang yang bisa ditemukan pada pasien MDS di antaranya:

1.Seri eritrosit:

  • binukleus
  • internuclear bridging
  • sisi inti iregular
  • perubahan megaloblastoid
  • ring sideroblast
  • cytoplasmic inclusion
  • cytoplasmic bridging
  • incomplete hemoglobinization
  • fringed cytoplasm
  • vakuolisasi

 

2.Seri leukosit

  • pseudo Pelger-Huet
  • hipogranulasi netrofil
  • hipersegmentasi netrofil
  • bizzare nuclear shape
  • granula pseudo Chediak-Higashi

 

3.Seri trombosit

  • bentuk monolobus berukuran besar
  • small binucleated elements
  • dispersed nuclei
  • micromegakaryocytes
  • degranulasi

 

Sumber:

Malcovati L, Lindberg EH, BowenD. 2013. Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet. Blood 122(17); 2943-2963